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Despite making efforts, those who remain deluded in their lives, are likely to remain deluded in their next life as well. This is explained in the next verse:
"Micchaa dansanarattaa saniyaanaa u hinsagaa ia je maranti jiivaa tesim puna dullahaa bohi."
~ Uttaraadhyayana Suutra; Verse 2.36.256 (Page 444, Author: Lilambai Mahasatiji, Publisher: Gurupraana Foundation, (Parasdham, Ghatakopar) Mumbai, year 2009)
One who has false belief and nidaana (seeks worldly favours as repayment for deeds of piety, self-control and penance) and whose soul is full of violence while he is on his deathbed is extremely unlikely to attain rational perception and enlightenment in his next life.
Also, as per the Uttaraadhyayana Suutra (verse 15.18), one who loses samyakdarshana after having attained it once finds it extremely difficult to attain it again.
If one who is fortunate enough to be born as a human does not practise any self-control and penance, he loses the opportunity to attain samaadhi yoga (deep immersion in the self). Such a person remains addicted to the pursuit of sensual pleasure and, devoid of samyakdarshana, he remains in transmigration for a long time. It is almost impossible for such a person to attain samyakdarshana.
As per the Uttaraadhyayana Suutra (verse 36.259), any living being who experiences such deep primeval passion that his soul darkens to the blackest shade while he breathes his last, is extremely unlikely to be blessed with true teachings and true insight in his next birth. Hence, once samyakdarshana is lost, it is extremely unlikely and difficult to regain it.
This is why Tirthankara Rishabhadeva told his 98 sons that,
"Sambujjhai kim na bujjhah, sambohi khalu pecha dullahaa. No huuvanamanti raaio, no sulabham punaraavi jiiviyam."
~Sutkritanga Suutra, Verse 1.2.1.1 (Page 111, Author: Yuvaachaarya Madhukarmuni, Publisher: Aagama Prakaasana Samiti, Byaawar, (Rajasthan) year 1982)
"O souls worthy of attaining liberation. Make efforts to attain true understanding. Why don't you? The nights that are spent, are lost forever and it is extremely difficult to be blessed with the life of an ascetic again."
Why do true teachings and comprehension become inaccessible to one who has lost samyaktva?
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