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The foolish ones, attached to the vile pleasures of the senses, abandon the noble endeavors. Alas! Dreadful is their state here!
The meaning is: Those who are attached to the vile, insignificant pleasures like the flesh of fish's neck, and the dreadful karmic fruits, abandon the noble spiritual practices. Alas! Dreadful is their state of ignorance!
The one who does not make the human birth meaningful by practicing the religion, but instead wastes it; who does not cultivate the seed of Dharma in the form of human birth, but instead lets it rot; who does not engage in righteous earning, but instead loses the capital out of greed - such a person engages in harmful activities instead of profit.
Just as a fish gets trapped and suffers greatly after being lured by the flesh of its own neck placed as bait, similarly the living being gets trapped and suffers terribly after being lured by the vile sensual pleasures placed by the deceitful 'fisherman'.
Just as the fish, due to the greed of the tongue, rushes towards the insignificant flesh and gets trapped, similarly the living being, due to the subjugation of the senses, becomes intoxicated and gets trapped. Thereafter, they experience dreadful sufferings of the hellish states.
Thus, due to the greed of the senses, just as the fish suffers, similarly the elephant intoxicated by pride gets bound, the moth burns itself in the flame, the bee drowns in the lotus, and the deer gets trapped in the hunter's net. In this way, the living being experiences dreadful karmic fruits due to the subjugation of each sense organ to its respective sense object.
Then, what to say about the one in whom all five senses are free - the one who delights in the cycle of births and deaths? Surely, they must experience immense suffering.
"O bees, moths, deer and others! Alas, they experience various pains due to the intoxicating taste of sensual pleasures. Woe unto them for their bitter end!"
- As said by Shri Vinayavijayaji in 'Shantasudharasam', the meaning is: Alas! Dreadful is their state of ignorance, which is the cause of their misery.