________________
in an undesirable effect in a different organ (such as the effect of PGE in stimulating contraction of the uterus). The synthesis of a number of prostaglandin analogues with more specific actions offers an alternative in obviating their nonspecific effects (14). (Table 4)
Table 4
Potential Therapeutic Applications of the Prostaglandins
Hypertension Bronchial asthma Anaphylactic shock Edema Induction of labor Induction of abortion Gastric hyperacidity and peptic ulceration Coronary and deep venous thrombosis Nasal congestion Infertility Cholera and Zollinger-Ellison syndrome (prostaglandrin antagonist) Glaucoma Burns
In contrast to PGE's and PGFs, PGA's can be given intravenously to produce antihypertensive effect since they do not stimulate nonvascular smooth muscle contraction. It is also possible that they may be effective orally and that their action is prolonged by production of analogues that are metabolized at a slower rate. The difference between prostaglandins and most other pharmaceuticals is that the former are naturally occurring, and their administration may constitute specific replacement therapy (such as the use of oral or parenteral PGA, in human beings with essential hypertension, whose disorder may be a genetic or acquired deficiency of PGA,)(14).
THE YE
MTS -- FGHET, 2006
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