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with prostaglandins is not so inhibited. PGE and PGE, are the most potent of all the prostaglandins, while the PGA and PGF classes are almost inactive. The evidence at present suggests that PGE compounds increase C-AMP, leading to decreased histamine release using a receptor other than that used by catecholamines.
GASTROINTESTINAL SYSTEM Intestinal Secretion
Intravenous administration of PGE, and PGA, to animals or humans or both inhibits the stimulation of gastric hydrochloric acid (HCL) secretion by histamine, pentagastrin, and food ingestion (12). Furthermore, in the rat, PGE, reduces the incidence of experimental ulcer formation resulting from pyloric ligation, a finding which has led to speculation that hypersecretion of gastric HCl causing Zollinger-Ellison syndrome and peptic ulcer may be due to a deficiency of prostaglandins normally located in all released from the stomach. Since C-AMP reduces gastric HCl secretion, it has been postulated that the mechanism of prostaglandin inhibition may be through activation of adenyl cyclase. Alternatively, a reduction in gastric mucosal blood flow could be the underlying mechanism. Intestinal Motility
PGE and PGF compounds which are normally present in the gastrointestinal tract are released by various stimuli and produce rhythmic contraction of longitudinal smooth muscle in vitro and, in the human being, in vivo. They appear to inhibit intestinal motility in the dog in vivo. It is believed that prostaglandins act directly on smooth muscle since the effects are only partially blocked by atropine. The role of prostaglandins in normal peristalsis remains to be clarified (12). METABOLIC AND ENDOCRINE SYSTEMS Adipose Tissue
The lipolytic effect of glucagons, ACTH, and epinephrine is inhibited by PGE, in vitro (3, 11). The lipolytic agents act by increasing fat-cell adenyl cyclase activity with a subsequent enhanced conversion of ATP to C-AMP. Theophylline, by inhibiting phosphodiesterase activity, also increases CAMP and lipolysis. PGE, is antilipolytic; however, it does not inhibit the
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TAH 4311 31ch 132-133
Jain Education International
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| SR No. | 524628 |
| Book Title | Tulsi Prajna 2006 07 |
| Original Sutra Author | N/A |
| Author | Shanta Jain, Jagatram Bhattacharya |
| Publisher | Jain Vishva Bharati |
| Publication Year | 2006 |
| Total Pages | 122 |
| Language | Hindi |
| Classification | Magazine, India_Tulsi Prajna, & India |
| File Size | 6 MB |